Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal
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منابع مشابه
Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential. Multiple stimuli that drive melanoma cell migration have been described, but it is not clear which are responsible for invasion, nor if chemot...
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Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients. The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside. They then migrate up this gradient, creating a complex and evolving outward chemotactic stimulus. Here, we introduce a new assay for self-generated che...
متن کاملLPP3, LPA and self-generated chemotactic gradients in biomedical science
ARTICLE HISTORY Received 6 October 2017 Accepted 25 October 2017 ABSTRACT Chemotaxis is a major driver of cancer spread, but in most cases we do not know where gradients of attractant come from. In the case of melanoma, chemotaxis to LPA is an important driver of metastasis, and the gradients are made by the tumour cells themselves, by locally breaking down ambient LPA. We have now made a gener...
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hen yeast secretory proteins are improperly folded, the ER quality control system directs them into the HRD/DER pathway, which targets the proteins for degradation. Blocking the HRD/DER pathway, however, does not completely stop degradation, implying that there must be an alternative way to destroy misfolded secretory proteins. Haynes et al., reporting on page 91, have now characterized that pa...
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Undifferentiated nasopharyngeal carcinoma (NPC) is a highly metastatic disease that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we have investigated the contribution of lysophosphatidic acid (LPA) signalling to the pathogenesis of NPC. Here we demonstrate two distinct functional roles for LPA in NPC. First, we show that LPA enhances the migration of NPC ce...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2014
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001966